Senior Manufacturing Manager - Downstream

Company: Amgen
Location: Holly Springs
Posted on: March 16, 2026

Job Description:

HOW MIGHT YOU DEFY IMAGINATION? Youveworked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience, and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over10 million patientsworldwide. Come do your bestworkalongside other innovative, driven professionals in this meaningful role. Be part of Amgen's newest and most advanced drug substance manufacturing plant. The AmgenFleXBatch facility combines the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. TheFleXBatch facility not only features the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it also integrates sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027. Senior Manager: Manufacturing Live What youwill do Letsdo this.Letschange the world.AsaSeniorManager ofManufacturing,you willprovide leadership and guidance tothe team responsible for24/7manufacturing operations indownstreampurification. In this vital role as a member of the Manufacturing leadership team, the Sr. Manager of Manufacturing will collaborate cross-functionally to enable the GMPto manufacturedrugsubstancein a new manufacturing facility. This roleis responsible forcoaching and developing DownstreamFront-Line Managerswho overseestaff supporting direct drug substance production.Additionally, you will beaccountablefororganizational design of the manufacturing team, hiring and development of staff, andensure staff is compliant withtraining programs to support safe andreliant operations.The position will also provide leadership and oversight for operational readiness activities to ensure successful facility start-up and sustained manufacturing performance. Responsibilities: Develop andretaina diverse and high performing teamin alignment with operational readinessschedules to ensure successfulstartupandcommercialGMP operations Maturethesitessafety and quality culture of the departmentand champion continued improvement Collaborateas one team of allmanufacturing support groups (Quality, Process Development, Engineering, Supply Chain, and network partners) Provide support to troubleshoot,identify,and resolve issues as needed and manage call coverage for 24/7operation Provide technical leadership for the investigation ofdeviations and the development of correctiveactions Develop and implement departmental strategy and plans that are aligned with the broader organizational strategyand deliver continuousimprovement Lead and support regulatory inspections for areas of responsibilities includingevaluating complex compliance issues anddevelopingplaybooks for the inspections Deliver against organizational financial commitments while championing a lean philosophy Win What we expectofyou We are all different, yet we all use our unique contributions to serve patients. The experienced professional weseekis a collaborative partner with these qualifications. Basic Qualifications: Doctorate degree and 2 years of Manufacturing & Operations experience Or Masters degree and 6 years of Manufacturing & Operations experience Or Bachelors degree and 8 years of Manufacturing & Operations experience Or Associate's degree and 10 years of Manufacturing & Operations experience Or High School diploma/GED and 12 years of Manufacturing & Operations experience AND2 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources Preferred Qualifications Demonstrated managerial experience in a GMP manufacturingdrug substanceplant Demonstrated experience in applying Operational Excellence and Lean Manufacturing Cross-functional work experience in either Process Development, Quality or Engineering Excellent communication skills, drive, sense of urgency, energy level and problem-solving abilities Demonstrated ability to forge and maintain strong relationships with other functional areas Ability to effectively develop and coach staff and positively advance the culture of an organization Thrive What you can expectofus As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being. Vast opportunities to learn and move up and across our global organization Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits Apply now for a career that defies imagination In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us. careers.amgen.com AmgenNorthCarolina

Keywords: Amgen, Greensboro , Senior Manufacturing Manager - Downstream, Manufacturing , Holly Springs, North Carolina