Senior Manufacturing Systems Engineer MES Platform Lead

Location: Holly Springs
Posted on: June 23, 2025

Job Description:

Join Amgen's Mission to Serve Patients If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of. Senior Manufacturing Systems Engineer MES Platform Lead Live What you will do Lets do this. Lets change the world. In this vital role as a Platform Lead you will drive the strategy, architecture, standards, and lifecycle for Amgens MES PASX ecosystem across a global network of manufacturing sites. You will collaborate closely with Site MES Teams, Development Teams, Business Teams, Subject Matter Experts and other stakeholders to maintain high-quality, high-value, scalable MES solutions that meet Amgens business needs. Own the global strategy and roadmap for the MES PASX platform which is used across all manufacturing sites; ensuring platform scalability, reliability, security, data integrity and business alignment. Define and maintain technical standards for the platform architecture and configuration, planning out improvements and removal of aging technology, ensuring adherence to PASX and Amgen best practices. Partner with the global Business Owner to co-own the business roadmap and standards for the system, creating alignment across the network and propagating best practices. Expand business usage of the platform to meet Amgens business goals. Serveas the principal Amgen SME for capital and expansion projects. Scope out MES deliverables for projects, and guide system integrator teams to achieve successful deployment and startup of systems, compliant with Amgen standards. Lead a Global Program for managing the lifecycle of MES PASX across the network. Work with MES System Owners at the sites to plan out and implement major and minor version upgrades to address bug fixes, cyber remediation, lifecycle upgrades. Maintain global procedures, configurations and qualification strategies for the MES Platform and work with site teams to ensure systems are maintained in accordance with Amgen and regulatory requirements. Work with business stakeholders in Manufacturing, Engineering, PD, and Data Science teams to help create and/or improve data products that utilize process and equipment data stored in MES, to fulfil business needs across the network. Own the strategic vendor relationship to manage contracts, SLAs, and technical engagement with Krber and key service partners; negotiate licensing & support terms, influence product roadmaps, and oversee escalation resolution. Apply best practices to analyse business requirements, develop architectural designs, evaluate technology solutions, and ensure alignment with industry best practices and standards. What we expect of you Basic Qualifications: Doctorate degree OR Masters degree and 4 to 6 years of Life Science/Biotechnology/Pharmacology/Information Systems experience OR Bachelors degree and 6 to 8 years of Life Science/Biotechnology/Pharmacology/Information Systems experience OR Diploma and 10 to 12 years of Life Science/Biotechnology/Pharmacology/Information Systems experience Preferred Qualifications Proven experience in designing, deploying, and maintaining Krbers PASX MES system. Handson with PASX along with associated integrations to Level 2 and Level 4 systems. Pharma / GxP regulatedenvironment experience. Strong background in industrial dataintegration protocols and platforms (MSI, OPCUA, Aveva Pi, Batch Management Systems, Kepware). Strong background in query languages and database technologies such as Oracle and PostgreSQL Customercentric mindset with a track record of building trusted stakeholder relationships. Selfmotivated and quick to learn new technologies; adept at crossfunctional collaboration. Functional Skills MustHave Deep understanding of manufacturing systems, data flows, and integrations. Strong grasp of OT/IT layering (ISA95/ISA99) and secure network design. Knowledge of load balancers, Windows Failover Clusters. Excellent problemsolving skills for complex manufacturing challenges. Collaborative communicator who thrives in crossfunctional teams. Commitment to continuous learning in digital and AI technologies. Skilled at crafting impactful slide decks and data storytelling Experience leading teams, coordinating stakeholders, and delivering projects on time. GoodtoHave Agile methodology practitioner. Design, deploy, and manage containerized applications using Kubernetes and Rafay. Implement and maintain CI/CD pipelines for automated deployment and scaling of applications. Monitor and optimize Kubernetes clusters for performance, security, and cost efficiency. Hybridcloud experience with AWS, Azure, or similar. Scripting & automation of system tasks with PowerShell or Python. Soft Skills Ability to influence and lead peers. Exceptional collaboration and communication abilities. High initiative and selfmotivation. Proven multitasker who manages priorities effectively. Teamoriented with a focus on shared success. Strong presentation and publicspeaking skills. Thrive What you can expect of us As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being. In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Keywords: , Greensboro , Senior Manufacturing Systems Engineer MES Platform Lead, IT / Software / Systems , Holly Springs, North Carolina